pentobarbital will minimize the level or impact of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Extensive-expression coadministration of solid CYP3A4 inducers with rolapitant may well appreciably lessen rolapitant efficacy.
pentobarbital will minimize the extent or impact of vinorelbine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.
Keep track of Closely (1)pentobarbital will decrease the extent or outcome of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will decrease the level or effect of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
pentobarbital will lessen the extent or outcome of zaleplon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.
pentobarbital will reduce the extent or result of amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Check Closely (two)pentobarbital will lessen the level or impact of buprenorphine, long-performing injection by impacting hepatic/intestinal enzyme CYP3A4 戊巴比妥鈉製作 metabolism. Modify Therapy/Check Closely. People who transfer to buprenorphine prolonged-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers should be monitored to be certain buprenorphine plasma degrees are ample.
Warning when discontinuing CYP3A4 inducers that are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well maximize and may end up in perhaps fatal respiratory despair.
pentobarbital will lessen the level or result of piroxicam by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Unfamiliar.
Contraindicated (1)pentobarbital will reduce the level or effect of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or effect of ritonavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will lessen the level or outcome of estrogens conjugated artificial by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.